Hepcinat-LP Ledipasvir and Sofosbuvir Tablets


Specifications:

  • Brand name: Hepcinat LP
  • Contents : Ledipasvir and Sofosbuvir
  • Manufactured by : Natco Pharma Ltd
  • Form: Tablets
  • Strength: Ledipasvir 90 mg and
  • Sofosbuvir 400 mg
  • Packing: Pack of 28 tablets

WHAT IS HEPCINAT LP ?

Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion. Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication. The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.

USES

Hepcinat LP  is a direct-acting antiviral (DAA) medication. DAAs are a group of medications that directly block the ability of the hepatitis C virus to make copies of itself.Harvoni is a combination of two DAAs. One is Sofosbuvir, which is a nucleotide polymerase inhibitor, and the other is Ledipasvir, which is an NS5A inhibitor. Sofosbuvir interferes with the reproduction of the virus’s genetic material, stopping the production of new Hep C virus. Ledipasvir works by interfering with a protein needed to complete the Hep C virus life cycle in the liver cell.

COMMON SIDE EFFECTS

  • Tiredness, headache, nausea, diarrhea, or difficulty sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
  • A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

WARNINGS & PRECAUTIONS

  • Before taking ledipasvir/sofosbuvir, tell your doctor or pharmacist if you are allergic to either of the drugs; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
  • Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease.
  • Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
  • During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Ledipasvir/sofosbuvir, in combination with ribavirin, must not be used during pregnancy by either the pregnant woman or her male partner. The combination may harm an unborn baby. Two reliable forms of birth control (such as condoms, birth control pills) must be used whenever at least one sexual partner is using these medicines together, and for six months after stopping treatment. If you or your partner becomes pregnant, or if you think you or your partner may be pregnant, tell your doctor right away.
  • It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding. Breast-feeding is not recommended if this medication is used in combination with ribavirin.

STORAGE

Store below 30°C (86°F). Dispense in original container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep ledipasvir and sofosbuvir out of the reach of children and away from pets.

LEDIPASVIR AND SOFOSBUVIR TABLETS INTERACTIONS

  • Some products that may interact with this drug include: amiodarone, a certain other medication used to treat chronic hepatitis C (simeprevir).
  • This medication can slow down the removal of other medications from your body, which may affect how they work. One example is rosuvastatin, among others.
  • Other medications can affect the removal of ledipasvir/sofosbuvir from your body, which may affect how this medication works. Examples include rifamycins (such as rifampin, rifabutin), St. John's wort, tipranavir/ritonavir, drugs used to treat seizures (such as phenobarbital, carbamazepine, phenytoin), among others.
  • Do not take this medication with other products that contain sofosbuvir.

This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.

DISPOSAL

Do not dispose of medications in wastewater (e.g. down the sink) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

NOTE

We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. The information contained in this website is meant to be helpful and educational, but is not a substitute for medical advice.