Ledifos: Ledipasvir 90mg & Sofosbuvir 400mg Tablets


Medicine Details

  • Brand name: Ledifos Tablets
  • Contents : Ledipasvir and Sofosbuvir
  • Manufactured by : Hetero Healthcare Limited
  • Form: Tablets
  • Strength: Ledipasvir 90 mg and Sofosbuvir 400 mg
  • Packing: Pack of 28 tablets

Ledifos 400mg Tablets


Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an relevant role in viral replication, assembly, and secretion. Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication. The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the enlarging RNA primer strand, resulting in viral chain termination.


Ledifos  is a direct-acting antiviral (DAA) medication. DAAs are a group of medications that directly block the ability of the hepatitis C virus to make copies of itself.Harvoni is a combination of two DAAs. One is Sofosbuvir, which is a nucleotide polymerase inhibitor, and the other is Ledipasvir, which is an NS5A inhibitor. Sofosbuvir interferes with the reproduction of the virus’s genetic material, stopping the production of new Hep C virus. Ledipasvir works by interfering with a protein needed to complete the Hep C virus life cycle in the liver cell.


  • Ledipasvir and sofosbuvir may cause some side effects. Tell your doctor if any of these symptoms are severe or do not go away :
  • Extreme tiredness; Unusual weakness or lack of energy; Confusion or memory problems; Slowed breathing;
  • Headache; Chest pain, slow heartbeats, weak pulse; Diarrhea etc.

Not all side effects are listed above. However, you should always inform your health care provider if you experience any unusual side-effects


Ledipasvir and sofosbuvir is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not use this medication without consult with your pharmacist, if you have :

  • severe kidney disease;
  • a hemoglobin blood cell disorder such as sickle-cell anemia or thalassemia etc.
  • kidney disease
  • liver problems other than hepatitis C etc.
  • While using Ledifos Hepatitis medicine, you may need frequent blood tests.
  • Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
  • Continue to take Ledifos even if you feel well. The length of your treatment depends on your condition, how well you respond to the medication, and whether you experience severe side effects.
  • Do not stop taking this medicine without talking to your pharmacist.Do not take this medication if you are allergic to Ledipasvir & Sofosbuvir or any ingredients of the medication.
  • Tell your doctor or dentist that you take LedifosHepatitis Medicine before you receive any medical or dental care, emergency care, or surgery.
  • If you take too much amount of this Hepatitis medicine, call your healthcare provider or go to the nearest hospital emergency room right away.

If you want to know more about this HCV drugs , please Contact with your health care provider.


  • Some products that may interact with this drug include: amiodarone, a certain other medication used to treat chronic hepatitis C (simeprevir).This medication can slow down the removal of other medications from your body, which may affect how they work. One example is rosuvastatin, among others.Other medications can affect the removal of ledipasvir/sofosbuvir from your body, which may affect how this medication works. Examples include rifamycins (such as rifampin, rifabutin), St. John's wort, tipranavir/ritonavir, drugs used to treat seizures (such as phenobarbital, carbamazepine, phenytoin), among others.
  • Do not take this medication with other products that contain sofosbuvir.Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Store below 30°C (86°F). Dispense in original container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep ledipasvir and sofosbuvir out of the reach of children and away from pets.


Do not place medicine in any dirty place.  Ask your pharmacist how to dispose of medications that are no longer needed or have expired.


We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. The information contained in this website is meant to be helpful and educational, but is not a substitute for medical advice.